Age-related decrease of ultraviolet light-induced DNA repair synthesis in human peripheral leukocytes.
نویسندگان
چکیده
The capacity for ultraviolet light-induced DNA repair synthesis, studied in peripheral leukocytes from 58 healthy subjects 13 to 94 years old, was found to vary greatly between individuals. A negative, statistically significant correlation was obtained between age and this synthesis, indicating a decrease in repair capacity with age. An age-related decrease in DNA repair may increase the susceptibility of cells to agents causing DNA damage, i.e. carcinogens and certain cytostatic drugs.
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عنوان ژورنال:
- Cancer research
دوره 39 7 Pt 1 شماره
صفحات -
تاریخ انتشار 1979